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Posts

Future Blog Post

less than 1 minute read

Published: January 01, 2199

This post will show up by default. To disable scheduling of future posts, edit config.yml and set future: false.

Blog Post number 4

less than 1 minute read

Published: August 14, 2015

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 3

less than 1 minute read

Published: August 14, 2014

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 2

less than 1 minute read

Published: August 14, 2013

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 1

less than 1 minute read

Published: August 14, 2012

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

portfolio

Portfolio item number 1

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Portfolio item number 2

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publications

Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance

Published in Biomed Opt Express, 2012, Google Scholar Link

Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation

Published in J Vis Exp, 2013, Google Scholar Link

Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy

Published in Am J Respir Crit Care Med, 2013, Google Scholar Link

Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology

Published in Chest, 2013, Google Scholar Link

Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography

Published in Chest, 2013, Google Scholar Link

Determination of multiphoton absorption of silk fibroin using the Z-scan technique

Published in Opt Express, 2013, Google Scholar Link

Highly tunable elastomeric silk biomaterials

Published in Adv Funct Mater, 2014, Google Scholar Link

Laser-based three-dimensional multiscale micropatterning of biocompatible hydrogels for customized tissue engineering scaffolds

Published in Proc Natl Acad Sci U S A, 2015, Google Scholar Link

Transparent, Nanostructured Silk Fibroin Hydrogels with Tunable Mechanical Properties

Published in ACS Biomater Sci Eng, 2015, Google Scholar Link

Biocompatible silk step-index optical waveguides

Published in Biomed Opt Express, 2015, Google Scholar Link

Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses

Published in Adv Mater, 2016, Google Scholar Link

A simple model of multiphoton micromachining in silk hydrogels

Published in Applied Physics Letters, 2016, Google Scholar Link

Bio-functionalized silk hydrogel microfluidic systems

Published in Biomaterials, 2016, Google Scholar Link

Dityrosine Cross-Linking in Designing Biomaterials

Published in ACS Biomater Sci Eng, 2016, Google Scholar Link

Evaluation of Silk Inverse Opals for "Smart" Tissue Culture

Published in ACS Omega, 2017, Google Scholar Link

Photo-induced structural modification of silk gels containing azobenzene side groups

Published in Soft Matter, 2017, Google Scholar Link

Directed assembly of bio-inspired hierarchical materials with controlled nanofibrillar architectures

Published in Nat Nanotechnol, 2017, Google Scholar Link

High-speed spatial frequency domain imaging with temporally modulated light

Published in J Biomed Opt, 2017, Google Scholar Link

Multi-distance diffuse optical spectroscopy with a single optode via hypotrochoidal scanning

Published in Opt Lett, 2018, Google Scholar Link

Quantitative real-time pulse oximetry with ultrafast frequency-domain diffuse optics and deep neural network processing

Published in Biomed Opt Express, 2018, Google Scholar Link

Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography

Published in Clin Cancer Res, 2019, Google Scholar Link

Quantitative assessment of airway remodelling and response to allergen in asthma

Published in Respirology, 2019, Google Scholar Link

Published in , 1900, Google Scholar Link

Modulation frequency selection and efficient look-up table inversion for frequency domain diffuse optical spectroscopy

Published in Journal of Biomedical Optics, 2020, Google Scholar Link

Recent advances in high speed diffuse optical imaging in biomedicine

Published in APL Photonics, 2020, Google Scholar Link

Dual-DMD hyperspectral spatial frequency domain imaging (SFDI) using dispersed broadband illumination with a demonstration of blood stain spectral monitoring

Published in Biomed Opt Express, 2021, Google Scholar Link

Real-Time Handheld Probe Tracking and Image Formation Using Digital Frequency-Domain Diffuse Optical Spectroscopy

Published in IEEE Trans Biomed Eng, 2021, Google Scholar Link

Self-supervised denoising of Nyquist-sampled volumetric images via deep learning

Published in Journal of Medical Imaging, 2023, Google Scholar Link

research

3D micropatterning silk hydrogels via three-photon absorption

Worked on in: 2015 – (<a href=https://www.pnas.org/doi/abs/10.1073/pnas.1509405112>Publication link</a>)

No cell in your body is more than a few hundreds of microns from a blood vessel. A key challenge for artificial organs is developing a biomimetic vasculature to support cell growth. In this work I used the large three-photon absorption cross section of silk fibroin to generate 3D structures in silk hydrogels that range in size from a few microns up to nearly a millimeter at unprecedented depths

Photocrosslinking silk with riboflavin

Worked on in: 2016 – (<a href=https://onlinelibrary.wiley.com/doi/10.1002/adma.201504527>Publication link</a>)

Silk is a great biocompatible, transparent substrate for all sorts of biomedical applications. One such is to use silk to patch corneal wounds. I developed a method to transform a liquid silk solution into a hydrogel when exposed to blue or UV light that binds readily to corneal tissue. A provisional patent on this method has been filed (62/268,993).

Multi-distance diffuse optical spectroscopy with a single optode via hypotrochoidal scanning

Worked on in: 2018 – (<a href=https://opg.optica.org/ol/fulltext.cfm?uri=ol-43-4-747&id=381448>Publication link</a>)

In diffuse optical spectroscopy, the distance between the source and detector fiber determines how deep below the surface detected light has traveled. Longer separation is more sensitive to deeper structures, while short separation is more sensitive to superficial changes. Many instruments rely on an array of different sources and detectors to build up 3D estimates of tissue hemoglobin. Here, I use mechanical scanning to trace the source and detector through a hypotrochoid which allows for a range of source/detector separations that are all centered at the same location. This allows measurements to form a pseudo axial line scan to build up 2- and 3-dimensional images of tissue chromophores.

OpenSFDI

Worked on in: 2020 – (<a href=https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-25/issue-01/016002/OpenSFDI--an-open-source-guide-for-constructing-a-spatial/10.1117/1.JBO.25.1.016002.full>Publication link</a>)

Spatial Frequency Domain Imaging is a diffuse optical imaging method able to quantify the concentration fo hemoglobin in tissue. OpenSFDI is a wesite that provides step-by-step instructions for building an SFDI system.

Real-time diffuse optical spectroscopy

Worked on in: 2021 – (<a href=https://ieeexplore.ieee.org/abstract/document/9399842>Publication link</a>)

Diffuse optical spectroscopy has a long history of use for the monitoring of breast cancer, but lengthy acquisition and processing times have made it difficult to use in the clinic. While in the Roblyer lab, I helped develop an ultrafast spectroscopy system with onboard data processing and integrated it with a novel probe tracking technique to provide real-time information of tissue hemodynamics.

Machine learning for imaging skin cancer with reflectance confocal microscopy

Worked on in: 2022

Reflectance confocal microscopy (RCM) is a noninvasive optical imaging modality capable of achieving cellular resolution that is currently used to rapidly diagnose skin cancer. I’m working on developing machine learning algorithms that will make it possible for the next generation of RCM microscopes smaller, faster, and cheaper.

Self-supervised denoising of volumetric biomedical images

Worked on in: 2023 – (<a href=https://pubmed.ncbi.nlm.nih.gov/36992871/>Publication link</a>)

Improving medical images with machine learning is hard because of the difficulty in collecting datasets that contain gold standard, or ground truth images. Self-supervised methods can learn to denoise images solely from noisy data. In this work, I show how similarities between adjacent images in a volume can be used to remove noise from a variety of volumetric biomedical image data.